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Det finnes lite dokumentasjon for effekt av kodein, tramadol, dekstropropoksyfen og pentazocin mot kroniske smerter. Statens legemiddelverk anbefaler samme retningslinjer for alle opioide analgetika ved behandling av langvarige smerter (6): Pasienten skal informeres grundig om virkninger og bivirkninger, spesielt om abstinens, avhengighet og misbru

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